Low-Autofluorescence unilateral fiber-optic patch cords selects the visible light of a specific material coating. Fluorescence suppression process is added in materials and processing, and Photobleaching test is conducted before delivery. This process saturates the fluorescent in the patch cords , so as to minimize the emission of spontaneous fluorescence, and more accurately measure the changes of fluorescence indicating the neural activity in the sample. It is suitable for LD and LED light sources.